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(S)-2-Chloropropanoyl chloride. A convenient reagent for the determination of the enantiomeric composition of α-substituted α-hydroxy acids

✍ Scribed by Henk Moorlag; Wim H. Kruizinga; Richard M. Kellogg

Publisher: Elsevier Science
Year: 2010
Tongue: English
Weight: 150 KB
Volume: 109
Category: Article
ISSN: 0165-0513
DOI: 10.1002/recl.19901090906

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✦ Synopsis

Abstract

(S)‐2‐Chloropropanoyl chloride reacts cleanly with α‐substituted α‐hydroxy acids (or esters) to give O‐acyl derivatives, which can be used for the establishment of optical purities of the acids or their esters.

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