Determination of disulfoton and its metabolites in the body fluids of a Di-Syston® intoxication case

✍ Scribed by M Yashiki; T Kojima; M Ohtani; F Chikasue; T Miyazaki

• Publisher: Elsevier Science
• Year: 1990
• Tongue: English
• Weight: 617 KB
• Volume: 48
• Category: Article
• ISSN: 0379-0738
• DOI: 10.1016/0379-0738(90)90107-a

✦ Synopsis

Disulfoton and its metabolites, two sulfoxides and two sulfones, in the body fluids of a patient who had ingested Di-Syston@ were analyzed by FPD-GC and GC/MS. After the chemicals in the extract (Fraction 1) obtained by Extrelute column extraction were analyzed, disulfoton and sulfoxides in Fraction 1 were oxidized into sulfones. The sulfones in the extract (Fraction 21 obtained by Extreluto column extraction were analyzed and the estimated concentrations of metabolite were calculated. The concentrations of disulfoton and the sum of the metabolites in the blood collected on admission were 0.093 nmollg (25.4 ng/gl and 4.92 nmol/g (corresponding to 1.35 pg/g of disulfotonl, respectively. These concentrations appear to indicate a severe level of disulfoton intoxication.