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Determination of desoxyepothilone B in nude mice plasma by liquid–liquid extraction and reversed-phase high-performance liquid chromatography

✍ Scribed by Zhi Wang; Hui Wang; Julie K. Rhie; Joseph M. Covey; Ping Liang; Shuyi Wang; Chun Wang; Yanxue Hu; Gautam Prasad; Li Nan; Donald L. Hill; Ruiwen Zhang


Book ID
111713314
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
133 KB
Volume
42
Category
Article
ISSN
0731-7085

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✍ D.A. Ogden; A.A. McKechnie; D.A. Bolton; R.B. Rankin; S.E. Dobbins; J.A. Clement 📂 Article 📅 1989 🏛 Elsevier Science 🌐 English ⚖ 388 KB

A method is described for the determination of pipothiazine in human plasma, based on reversed-phase HPLC. The method has been applied in a pharmacokinetic study of pipothiazine in six psychiatric patients receiving repeated depot intramuscular injections for six months. A number of compounds likely