Determination of pipothiazine in human plasma by reversed-phase high-performance liquid chromatography

✍ Scribed by D.A. Ogden; A.A. McKechnie; D.A. Bolton; R.B. Rankin; S.E. Dobbins; J.A. Clements

• Publisher: Elsevier Science
• Year: 1989
• Tongue: English
• Weight: 388 KB
• Volume: 7
• Category: Article
• ISSN: 0731-7085
• DOI: 10.1016/0731-7085(89)80131-1

✦ Synopsis

A method is described for the determination of pipothiazine in human plasma, based on reversed-phase HPLC. The method has been applied in a pharmacokinetic study of pipothiazine in six psychiatric patients receiving repeated depot intramuscular injections for six months. A number of compounds likely to be taken concurrently by patients were tested for potential to interfere with the assay. There was no evidence of "dose-dumping" in the period following injection. Comparison of the pharmacokinetic profiles after the first and sixth injections showed no evidence of drug accumulation.