Determination of “Brompton's cocktails” by circular dichroism
✍ Scribed by W. Marc Atkinson; John M. Bowen; Neil Purdie
- Publisher
- John Wiley and Sons
- Year
- 1984
- Tongue
- English
- Weight
- 218 KB
- Volume
- 73
- Category
- Article
- ISSN
- 0022-3549
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A study of the applicability of circular dichroism (CD) for the determination of drug levels in human serum is described and a new method for the quantitative determination of optically active absorbing drugs having Cotton effects at wavelengths about 250 nm in human serum and/or plasma is proposed.
## Abstract Two brominated sesquiterpenes, majapolene B (**1**) and acetylmajapolene B (**2**), isolated from the red algal genus __Laurencia__ were investigated using vibrational circular dichroism (VCD). The ab initio theoretical VCD and IR calculations of **1** and **2** were performed by densit
The absolute configuration of the (À)-enantiomer of mirtazapine was determined by means of vibrational circular dichroism (VCD). The observed VCD of (À)-mirtazapine showed excellent correlation with the calculated VCD of the (R)-enantiomer. This is in agreement with the absolute configuration as det