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Determination of aditoprim and its oxidative metabolites in plasma and microsomal incubation mixtures by high-performance liquid chromatography

✍ Scribed by M. Alvinerie; J.F. Sutra; C. Eeckhoutte; P. Galtier; G.A.E van 't Klooster; A.S.J.P.A.M. van Miert

Publisher
Elsevier Science
Year
1993
Weight
502 KB
Volume
612
Category
Article
ISSN
0378-4347

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Encainide (ENC) and its metabolites O-demethylencainide (ODE), 3-methoxy-O-demethylencainide (MODE), N-demethylencainide (NDE) and bis-N,O-demethylencainide (NODE) have been measured by two HPLC procedures. The method of Mayol using a mu Porasil column with ethanol-water-methanesulphonic acid as mob