Determination of acid dissociation constants based on continuous titration by feedback-based flow ratiometry
✍ Scribed by Hideji Tanaka; Takahiro Tachibana; Risa Oda; Purnendu K. Dasgupta
- Book ID
- 116900646
- Publisher
- Elsevier Science
- Year
- 2004
- Tongue
- English
- Weight
- 196 KB
- Volume
- 64
- Category
- Article
- ISSN
- 0039-9140
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## Abstract CZE was employed to determine acid–base dissociation constants (p__K__~a~) of ionogenic groups of azahelicenes in methanol (MeOH). Azahelicenes are unique 3‐D aromatic systems, which consist of __ortho__‐fused benzene/pyridine units and exhibit helical chirality. The p__K__~a~ values of
Nonlogarithmic graphical treatments of acid/base titration data are presented which can identify and compensate for unknown contaminations of a compound by either a strong mineral acid or base. The methods which have been demonstrated allow an accurate determination of an acid dissociation constant