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Determination of a minimal region of loss of heterozygosity on chromosome 18q21.33 in osteosarcoma

✍ Scribed by Teresa L. Johnson-Pais; Maggie J. Nellissery; Donald G. Ammerman; Dharmini Pathmanathan; Pardeep Bhatia; Carolyn L. Buller; Robin J. Leach; Marc F. Hansen

Publisher: John Wiley and Sons
Year: 2003
Tongue: French
Weight: 131 KB
Volume: 105
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.11070

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✦ Synopsis

Abstract

Previous analysis of tumor‐specific constitutional LOH had identified a putative tumor‐suppressor gene (LOH18CR) active in osteosarcoma tumorigenesis, which mapped to a subregion of chromosome 18q linked to both familial Paget's disease and FEO. Using 9 new polymorphic loci within the previous minimal region of LOH, we have reduced the minimal region of LOH in osteosarcoma tumors to localize the LOH18CR locus to the distal end of chromosome 18q21.33. This new region is approximately 500 kb and contains at least 7 known genes; however, it excludes 2 previous candidate genes: TNFRSF11A (RANK) and BCL2. © 2003 Wiley‐Liss, Inc.

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