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Determination of 5-Fluorouracil in Plasma with HPLC-Tandem Mass Spectrometry

✍ Scribed by van Kuilenburg, A. B. P.; van Lenthe, H.; Maring, J. G.; van Gennip, A. H.


Book ID
120581738
Publisher
Taylor and Francis Group
Year
2006
Tongue
English
Weight
329 KB
Volume
25
Category
Article
ISSN
0732-8311

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A gas chromatography-mass spectrometry (GC-MS) method for the simultaneous determination of 5'-deoxy-Sfluorouridine (doxifluridine, 5'-dFUR), 5fluorouracil (5-FU) and its main catabolite 5,6-dihydro-5-fluorouracil (5-FUH\*) in human plasma has been developed. Sample preparation consisted of protein