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Determination of 5-aminolevulinic acid in biological samples by high-performance liquid chromatography

✍ Scribed by Hans-Ulrich Meisch; Wolfgang Reinle; Ursula Wolf

Publisher
Elsevier Science
Year
1985
Tongue
English
Weight
445 KB
Volume
149
Category
Article
ISSN
0003-2697

No coin nor oath required. For personal study only.

✦ Synopsis

5-Aminolevulinic acid (ALA), the common precursor of all naturally occurring tetrapyrroles, forms a stable condensation product with 2-amino-3-hydroxynaphthafene which can be identified by its fluorescence. Separation of the compound by reversed-phase high-performance liquid chromatography on RPC-18 columns allows its detection down to the picomolar range and can be successfully applied for ALA analysis in small biological samples. The reaction product of ALA with 2-amino-3-hydroxynaphthalene has been synthesized and characterized.

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