✦ LIBER ✦

Determination of 4-aminopyridine in plasma

✍ Scribed by Eric Watson

Book ID: 102627901
Publisher: Elsevier Science
Year: 1981
Tongue: English
Weight: 431 KB
Volume: 113
Category: Article
ISSN: 0003-2697
DOI: 10.1016/0003-2697(81)90056-7

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✦ Synopsis

Gas-liquid chromatographic procedures for the determination of 4-aminopyridine in human and animal plasma are reported. The procedures involve the addition of an internal standard 3-methyl-4-aminopyridine to plasma followed by extraction into methylene chloride/isopropranol under alkaline conditions. The isolated amines are converted to their pentafluoropropionyl or monochlorodifluoracetyl derivatives and are quantified after chromatographic separation using either electron-capture or nitrogen-phosphorus detectors. The sensitivity of these procedures is such that nanogram amounts of 4-aminopyridine can be readily determined.

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