A general and versatile synthesis of 2-a
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Vidyadhar B Hegde; James M Renga; John M Owen
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Article
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2001
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Elsevier Science
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French
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A versatile two-step synthesis of 2-alkyl-4-aminopyridines from commercially available cis-1-methoxy-1-buten-3-yne is described. Acylation of the yne derivative followed by amination and cyclization in ammonia produced the desired substituted pyridines in high yield.