A general and versatile synthesis of 2-alkyl-4-aminopyridines
β Scribed by Vidyadhar B Hegde; James M Renga; John M Owen
- Publisher
- Elsevier Science
- Year
- 2001
- Tongue
- French
- Weight
- 77 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0040-4039
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β¦ Synopsis
A versatile two-step synthesis of 2-alkyl-4-aminopyridines from commercially available cis-1-methoxy-1-buten-3-yne is described. Acylation of the yne derivative followed by amination and cyclization in ammonia produced the desired substituted pyridines in high yield.
π SIMILAR VOLUMES
## Abstract The quasiβone pot synthesis of new 2βaminopyrido[1,2β__a__][1,3,5]triazinβ4βones starting from 2βaminoβpyridine and 2βaminopicolines is herein described in order to obtain a library of cyclic guanidines.
In -No. 32 Scheme I R(R')CO + OC(SCH3)3 R(R~)c-cO-CHR~~C~~~-BU