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Determinants of tissue delivery for 129Xe magnetic resonance in humans

✍ Scribed by Sharon Peled; Ferenc A. Jolesz; Ching-Hua Tseng; Luigino Nascimben; Mitchell S. Albert; Ronald L. Walsworth

Publisher
John Wiley and Sons
Year
1996
Tongue
English
Weight
443 KB
Volume
36
Category
Article
ISSN
0740-3194

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✦ Synopsis

Abstract

Magnetic resonance imaging using laser‐polarized ^129^Xe is a new technique first demonstrated by Albert et al. (Nature 370, 1994) who obtained a ^129^Xe image of an excised mouse lung. This paper describes the factors influencing the accumulation of inhaled, polarized ^129^Xe in human tissue. The resulting model predicts the ^129^Xe magnetization in different tissues as a function of the time from the start of inhalation, the tissue perfusion rate and partition coefficient for xenon, and the relevant T~1~ decay times. The relaxation times of ^129^Xe in biological tissues are not yet known precisely. Substitution of estimated values for these parameters results in an expected signal‐to‐noise ratio (SNR) from polarized ^129^Xe MR in the brain of approximately 2% of the equivalent SNR from proton MR.

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