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Determinants of survival after intraarterial infusion of 5-fluorouracil for liver metastases from colorectal cancer: A multivariate analysis

✍ Scribed by Dr. Henrik Ekberg; Karl-Göran Tranberg; Christer Lundstedt; Gunnar Hanff; Jonas Ranstam; Bengt Jeppsson; Stig Bengmark

Publisher
John Wiley and Sons
Year
1986
Tongue
English
Weight
746 KB
Volume
31
Category
Article
ISSN
0022-4790

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✦ Synopsis

A consecutive series of 73 patients treated with intraarterial infusion of 5fluorouracil (5-FU) for liver metastases from colorectal primary was studied retrospectively using multivariate analysis in order to find determinants of survival. Nontreatment factors had a great impact on variation in survival with liver tumor volume and metastases to lymph glands in the liver hilum as major prognostic determinants. in addition, survival from onset of treatment varied with the interval between the primary operation and the diagnosis of liver metastases. Treatment with intraarterial 5-FU was more effective when administered at long-term (3 months every 6 months) than at short-term (5 days every 6 weeks). Single temporary dearterialization, used as an adjunct to infusion of 5-FU, had a negative impact on length of survival and was followed by a high frequency of complications. The occurrence of hepatic arterial thrombosis was associated with comparatively good prognosis.

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