Treatment of liver metastases from colorectal cancer with hepatic artery occlusion, intraportal 5-fluorouracil infusion, and oral allopurinol. A randomized clinical trial

✍ Scribed by Larsolof Hafström; Boel Engaräs; Stig B Holmberg; Bengt Gustavsson; Per-Ebbe Jönsson; Per Lindnér; Peter Naredi; Göran Tidebrant

• Publisher: John Wiley and Sons
• Year: 1994
• Tongue: English
• Weight: 688 KB
• Volume: 74
• Category: Article
• ISSN: 0008-543X
• DOI: 10.1002/1097-0142(19941115)74:10<2749::aid-cncr2820741003>3.0.co;2-m

✦ Synopsis

Background. Regional therapy for colorectal liver metastases aimed at prolonging survival has not been tested fully in a randomized trial with untreated control subjects. This study explored the efficacy of temporary hepatic artery occlusion followed by intraportal infusion of 5-fluorouracil[5-FU) and oral allopurinol as biochemical modulators in prolonging the survival of patients with nonresectable liver metastases and no extrahepatic cancer.

Methods. Eighty-four patients were considered for randomization, of whom 24 were excluded at laparotomy because of extrahepatic cancer (n = 17) or resectable lesions (n = 5). In two patients, no cancer was identified in the liver. Thirty-two patients were allocated to receive treatment, and 28 were allocated to receive no regional or systemic treatment. Six patients were excluded after randomization because of major protocol violations.

Results. The median survival time for patients was 1 7 months (range, 0-66), and for control subjects, the me-~ From the