𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Determinants of head and neck cancer survival by race

✍ Scribed by Camille C. Ragin; Scott M. Langevin; Mark Marzouk; Jennifer Grandis; Emanuela Taioli

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
110 KB
Volume
33
Category
Article
ISSN
1043-3074

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Background

Several factors contribute to the documented racial disparity in head and neck cancer, among which are socioeconomic status, access to care, and biologic factors.

Methods

Clinical characteristics of 87 African‐American patients with head and neck cancer and a random sample of 261 white patients matched on age and smoking dose were associated with outcome.

Results

Black patients with cancers of the oral cavity and larynx were more likely diagnosed with advanced stages than whites, after adjusting for socioeconomic and insurance status and other confounding factors. There was a significant difference in relapse‐free survival between blacks and whites with tumors of the larynx (hazard ratio [HR] = 3.36, 95% confidence interval [CI]: 1.62–7.00), but not with tumors of the oral cavity or pharynx.

Conclusions

Differences in disease outcome may be attributed to a combination of tumor stage, socioeconomic status, and access to health care. The inclusion of biologic markers such as human papillomavirus (HPV) status is needed in future studies to further evaluate racial disparities in head and neck cancer outcomes. Β© 2010 Wiley Periodicals, Inc. Head Neck, 2011

πŸ“œ SIMILAR VOLUMES

Survival of patients with palliative hea
Survival of patients with palliative head and neck cancer
✍ Quirine C. P. Ledeboer; Marc P. van der Schroeff; Jean F. A. Pruyn; Maarten F. d πŸ“‚ Article πŸ“… 2010 πŸ› John Wiley and Sons 🌐 English βš– 296 KB πŸ‘ 2 views

## Abstract ## Background The purpose of this study was to describe patient characteristics and prognostic factors for survival in the palliative stage of patients with head and neck cancer. ## Methods Since November 2003, all patients with palliative head and neck cancer treated in our hospital

Prediction of survival in patients with
Prediction of survival in patients with head and neck cancer
✍ Robert Jan Baatenburg de Jong; Jo Hermans; Jan Molenaar; Jeroen Johannes Briaire πŸ“‚ Article πŸ“… 2001 πŸ› John Wiley and Sons 🌐 English βš– 363 KB πŸ‘ 2 views

## Background: In patients with head and neck squamous cell carcinoma (hnscc) the estimated prognosis is usually based on the tnm classification. the relative weight of the three contributing parameters is often not completely clear. moreover, the impact of other important clinical variables such a

Glutathione S-transferase polymorphisms
Glutathione S-transferase polymorphisms and survival from head and neck cancer
✍ Stacy A. Geisler; Andrew F. Olshan; Jianwen Cai; Mark Weissler; Joanna Smith; Do πŸ“‚ Article πŸ“… 2005 πŸ› John Wiley and Sons 🌐 English βš– 445 KB πŸ‘ 1 views

Background. The purpose of this study was to evaluate the prognostic ability of polymorphisms of three genes involved in the metabolism of tobacco carcinogens (GSTT1, GSTM1, GSTP1) and one polymorphism of a DNA repair gene (XRCC1) for patients diagnosed with squamous cell carcinoma (SCC). Methods.

Molecular pathology of head-and-neck can
Molecular pathology of head-and-neck cancer
✍ Michael M. Kim; Joseph A. Califano πŸ“‚ Article πŸ“… 2004 πŸ› John Wiley and Sons 🌐 French βš– 113 KB πŸ‘ 2 views

## Abstract Each year approximately 40,000 people in the United States and 500,000 people worldwide are diagnosed with head‐and‐neck squamous cell carcinoma (HNSC). Although there have been significant improvements in the treatment of this disease, leading to decreased morbidity, over the past few