✦ LIBER ✦

Determinants of carotid artery wall thickening in young patients with Type 1 diabetes mellitus

✍ Scribed by Frost, D.; Beischer, W.

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 121 KB
Volume: 15
Category: Article
ISSN: 0742-3071
DOI: 10.1002/(sici)1096-9136(199810)15:10<851::aid-dia660>3.0.co;2-9

No coin nor oath required. For personal study only.

✦ Synopsis

To investigate associations between early atherosclerosis and possible risk factors for it in young patients with established Type 1 diabetes mellitus (DM), we measured the combined intima-media thickness (IMT) of the common carotid arteries with high resolution ultrasound in 310 young patients (age Յ 40 years, mean 27.9 ± 6.5) with a diabetes duration Ն 2 years, and in two control groups of similar age (control 1:40 healthy subjects, control 2: 40 Type 1 DM recently diagnosed patients). Albumin excretion rate and lipids (total cholesterol and triglycerides) were measured and retinopathy and hypertension (systolic blood pressure Ͼ 140 or diastolic blood pressure Ͼ 90 mmHg) sought in the patients. Mean maximum IMT was 0.52 ± 0.06 mm in control group 1 and 0.50 ± 0.05 mm in control group 2 with a mean difference of 0.02 mm (95% CI: -0.01, 0.04). The more established Type 1 DM patients had a significantly greater IMT (0.57 ± 0.13 mm, p Ͻ 0.001) than both control groups. In a subgroup analysis, patients with microvascular diabetic complications (n = 99) had a significantly greater IMT (0.63 ± 0.17 vs 0.55 ± 0.10 mm, p Ͻ 0.001) than those without (n = 211). In a multiple linear regression analysis with a significance level of Յ 0.10, the carotid artery IMT of our established diabetic patients was related to age, male gender, triglycerides and nephropathy, suggesting the latter as the main diabetes-specific risk for intima-media thickening in young Type 1 DM patients.

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