Apolipoprotein E genotype is a determinant of low-density lipoprotein cholesterol and of its response to a low-cholesterol diet in Type 1 diabetic patients with elevated urinary albumin excretion
✍ Scribed by Blaauwwiekel, E.E.; Beusekamp, B.J.; Sluiter, W.J.; Hoogenberg, K.; Dullaart, R.P.F.
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 76 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0742-3071
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✦ Synopsis
The effect of the apolipoprotein (apo) E genotype on the lipoprotein response to a 1 year low cholesterol diet (200 mg cholesterol per day) was evaluated in 36 patients with Type 1 diabetes mellitus with albuminuria between 10 and 200 g min ؊1 . Apo E genotype was characterized by polymerase chain reaction and restriction isotyping. In 11 IDDM patients with at least one ⑀4 allele (apo E4 group), baseline serum total and low density lipoprotein (LDL) cholesterol were higher (p Ͻ 0.05 for both) than in 25 patients without an ⑀4 allele and with at least one ⑀3 allele (apo E3 group). Dietary counselling resulted in a similar decrease in cholesterol intake in both groups, whereas linoleic acid did not change. In the apo E4 group, serum total and LDL cholesterol at follow-up fell (p Ͻ 0.01 for both) to levels that were not different from those in the apo E3 group, and the changes in these parameters were greater (p Ͻ 0.02) than those in the apo E3 group. We conclude that the apo E4 allele is associated with atherogenic lipoprotein abnormalities in Type 1 DM patients with minor elevations in albuminuria when they use their habitual diet. Apo E4 carrying patients respond better to a low cholesterol diet.