Detection ofETV6gene rearrangements in adult acute lymphoblastic leukemia
โ Scribed by Zhou, Min-hang; Gao, Li; Jing, Yu; Xu, Yuan-yuan; Ding, Yi; Wang, Nan; Wang, Wei; Li, Mian-yang; Han, Xiao-ping; Sun, Jun-zhong; Wang, Li-li; Yu, Li
- Book ID
- 113027952
- Publisher
- Springer
- Year
- 2012
- Tongue
- English
- Weight
- 289 KB
- Volume
- 91
- Category
- Article
- ISSN
- 0939-5555
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## Background: Loss of heterozygosity (loh) at the atm gene (mutated in ataxia telangiectasia [at] patients) and atm protein deficiency occur in 14% and 34%, respectively, of patients with chronic lymphocytic leukemia (cll). atm protein deficiency also is associated with aggressive disease and wors
The recurring chromosomal 9; I I translocation [t(9; I I ) (p22;q23)] typically is associated with acute monoblastic leukemia, but a number of patients with acute lymphoblastic leukemia also have been reported to have the t(9;l I). To investigate the cell lineage in the latter cases, we analyzed DNA