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Detection of Y-specific sequences in patients with Turner syndrome

✍ Scribed by Hall, Judith G.


Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
25 KB
Volume
113
Category
Article
ISSN
0148-7299

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Cytogenetic analysis of patients with Ullrich-Turner syndrome (UTS) may fail to detect low levels of Y chromosome mosaicism or Y-derived marker chromosomes. More sensitive polymerase chain reaction (PCR)-based tests have been developed; however, applicability of these data to prognosis of virilizati

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Cytogenetic studies have shown that 40-60% of patients with Ullrich-Turner syndrome (UTS) are 45,X, whereas the rest have structural aberrations of the X chromosome or mosaicism with a second cell line containing a structurally normal or abnormal X or Y chromosome. However, molecular analysis has de