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Detection of trophoblastic tumour activity by pregnancy-specific beta-1-glycoprotein

✍ Scribed by M. Seppälä; Eeva-Marja Rutanen; M. Heikinheimo; H. Jalanko; Eva Engvall

Publisher
John Wiley and Sons
Year
1978
Tongue
French
Weight
295 KB
Volume
21
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

Pregnancy‐specific beta‐1‐glycoprotein (PSBG) and human chorionic gonadotrophin (hCG) were measured by specific radioimmunoassays in 73 serum samples from eight patients treated for gestational choriocarcinoma. Both markers were initially present in all cases, but at the time of writing both had levelled off in six cases and decreased markedly in two. Usually hCG was detectable for longer than PSBG during the course of chemotherapy. Both PSBG and hCG reappeared on clinical recurrence. However, at times during the follow‐up period one trophoblastic marker only was expressed This was hCG in most cases, but in one case PSBG alone was encountered. These results suggest that PSBG may serve as an additional marker for the detection of residual tumour growth in patients with trophoblastic tumours.

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Development of a radioimmunoassay for pr
Development of a radioimmunoassay for pregnancy-specific beta1-globulin and its measurement in serum of patients with trophoblastic and non-trophoblastic tumours
✍ Yu.S. Tatarinov; A. V. Sokolov 📂 Article 📅 1977 🏛 John Wiley and Sons 🌐 French ⚖ 493 KB

## Abstract Levels of human pregnancy‐specific or trophoblast‐specific beta~1~‐globulin (TBG) were measured by double‐antibody radioimmunoassay (RIA) in 103 patients with trophoblastic tumours and in 114 patients with a variety of non‐trophoblastic tumours. The sensitivity of RIA for TBG was about