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Detection of the amine derivative of misonidazole in human urine by high-pressure liquid chromatography

โœ Scribed by A.J. Varghese

Publisher
Elsevier Science
Year
1981
Tongue
English
Weight
267 KB
Volume
110
Category
Article
ISSN
0003-2697

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โœฆ Synopsis

A sensitive high-pressure liquid chromatographic assay for the detection and quantitation of the amine derivative of misonidazole in human urine is reported. The amine was converted to its dansyl derivative and was separated on a reverse-phase PBondapak phenyl column. Absorbance at 365 nm was monitored for the detection of the dansvl derivative. Using this procedure, the amine derivative has been identified as a urinary metaboiite of misonidazole.

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