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Detection of SSEA-1 on human renal tumors

โœ Scribed by Monica Liebert; Ronald Jaffe; Rodney J. Taylor; Byron T. Ballou; Davor Solter; Thomas R. Hakala

Publisher
John Wiley and Sons
Year
1987
Tongue
English
Weight
623 KB
Volume
59
Category
Article
ISSN
0008-543X

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โœฆ Synopsis

Stage-specific embryonic antigen-1 (SSEA-1) was localized on paraffin embedded, formalin fixed specimens of human renal tumors by immunoperoxidase staining using a monoclonal antibody. Of 19 renal cell carcinoma (RCC) samples tested, 12 were positive for SSEA-1; SSEA-1 was also found on distinct elements in two samples of Wilms' tumor. No correlation was found between expression of SSEA-1, and RCC morphology or pattern of growth. Because SSEA-1 is found on proximal tubules in the normal kidney, these results support the hypothesis that RCC arises from the cells of the proximal tubule. Furthermore, since >60% of the RCCs examined expressed SSEA-1, this antigen may prove to be a useful target for immunolocation or therapy of metastatic RCC.

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