𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Detection of specific IgA antibodies against BK virus by ELISA

✍ Scribed by Ingard Nilsen; Dr. Trond Flægstad; Terje Traavik

Book ID
102909007
Publisher
John Wiley and Sons
Year
1991
Tongue
English
Weight
591 KB
Volume
33
Category
Article
ISSN
0146-6615

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✦ Synopsis

The development and evaluation of an ELISA for analysis of anti-BKV specific IgA antibodies in human sera are described. All children with cancer with a primary BKV infection developed specific IgA antibodies, without any specific symptoms during the infection. Specific IgA was found in 61% of sera from healthy persons containing BKV IgG antibodies, using the chosen cut-off value, and BKV IgM in 4%. These results indicate that IgA production is more persistent than IgM. The high frequency of specific IgA antibodies could either be explained by frequent reactivations or long-lasting persistence of antibodies.

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