Detection of SNP-SNP interactions in trios of parents with schizophrenic children

✍ Scribed by Qing Li; M. Daniele Fallin; Thomas A. Louis; Virginia K. Lasseter; John A. McGrath; Dimitri Avramopoulos; Paula S. Wolyniec; David Valle; Kung-Yee Liang; Ann E. Pulver; Ingo Ruczinski

• Publisher: John Wiley and Sons
• Year: 2010
• Tongue: English
• Weight: 146 KB
• Volume: 34
• Category: Article
• ISSN: 0741-0395
• DOI: 10.1002/gepi.20488

✦ Synopsis

Abstract

Schizophrenia (SZ) is a heritable and complex psychiatric disorder with an estimated worldwide prevalence of about 1%. Research on the risk factors for SZ has thus far yielded few clues to causes, but has pointed to a heterogeneous etiology that likely involves multiple genes and gene‐environment interactions. In this manuscript, we apply a novel method (trio logic regression, Li et al., 2009) to case‐parent trio data from a SZ candidate gene study conducted on families of Ashkenazi Jewish descent, and demonstrate the method's ability to detect multi‐gene models for SZ risk in the family‐based design. In particular, we demonstrate how this method revealed a genotype‐phenotype association that includes an allele without marginal effect. Genet. Epidemiol. 34: 396–406, 2010. © 2010 Wiley‐Liss, Inc.