Detection of serum antibodies to retroviral proteins in patients with primary sjögren's syndrome (autoimmune exocrinopathy)
✍ Scribed by Professor Norman Talal; Professor Michael J. Dauphinée; Assistant Professor Howard Dang; Steve S. Alexander; Darrenn J. Hart; Robert F. Garry
- Publisher
- John Wiley and Sons
- Year
- 1990
- Tongue
- English
- Weight
- 691 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0004-3591
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Sixty-four consecutive patients with clinically or laboratory-supported definite multiple sclerosis (MS) were evaluated prospectively for evidence of primary Sjiigren's syndrome (SS). This diagnosis was established when a patient had objective keratoconjunctivitis sicca, xerostomia, or both together
## Abstract ## Objective To delineate disturbances in peripheral B cell memory in primary Sjögren's syndrome (SS). ## Methods Isotype‐specific immunoglobulin (Ig) heavy‐chain transcripts were analyzed in single‐sorted CD19+,CD27− naive and CD19+,CD27+ memory B cells from patients with primary SS