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Detection of P-glycoprotein in the Golgi apparatus of drug-untreated human melanoma cells

✍ Scribed by Agnese Molinari; Annarica Calcabrini; Stefania Meschini; Annarita Stringaro; Donatella Del Bufalo; Maurizio Cianfriglia; Giuseppe Arancia

Publisher
John Wiley and Sons
Year
1998
Tongue
French
Weight
979 KB
Volume
75
Category
Article
ISSN
0020-7136

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## Abstract Because solid growing tumors often show hypoxia and pronounced extracellular acidosis, the aim of this study was to analyze the impact of an acidotic environment on the activity of the p‐glycoprotein (pGP) and on the cellular content and cytotoxicity of the chemotherapeutic drug daunoru