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Detection of Noncovalent Complexes in Biological Samples by Intensity Fading and High-Mass Detection MALDI-TOF Mass Spectrometry

✍ Scribed by Yanes, Oscar; Nazabal, Alexis; Wenzel, Ryan; Zenobi, Renato; Aviles, Francesc X.


Book ID
127310231
Publisher
American Chemical Society
Year
2006
Tongue
English
Weight
235 KB
Volume
5
Category
Article
ISSN
1535-3893

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## Abstract A simple method for the detection of specific RNA‐polypeptide interactions using MALDI‐TOF mass spectroscopy is described. Instead of direct observation of the RNA‐polypeptide complex, we attempted the indirect observation of the binding event by focusing on the disappearance of the fre