𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Detection of multiple H3 receptor affinity states utilizing [3H]A-349821, a novel, selective, non-imidazole histamine H3 receptor inverse agonist radioligand

✍ Scribed by David G Witte; Betty Bei Yao; Thomas R Miller; Tracy L Carr; Steven Cassar; Rahul Sharma; Ramin Faghih; Bruce W Surber; Timothy A Esbenshade; Arthur A Hancock; Kathleen M Krueger


Book ID
110009142
Publisher
Nature Publishing Group
Year
2006
Tongue
English
Weight
444 KB
Volume
148
Category
Article
ISSN
0007-1188

No coin nor oath required. For personal study only.


📜 SIMILAR VOLUMES


Discovery of a New Class of Non-imidazol
✍ Sylvain Célanire; Maikel Wijtmans; Bernard Christophe; Philippe Collart; Iwan de 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 428 KB 👁 2 views

## Abstract **H**~**3**~**R inverse agonists** based on an aminopropoxy‐phenyloxazoline framework constitute highly valuable druglike lead compounds that display efficacy in a mouse model of recognition memory.magnified image

Inside Cover: Tritium-Labeled N1-[3-(1H-
✍ Patrick Igel; David Schnell; Günther Bernhardt; Roland Seifert; Armin Buschauer; 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 393 KB 👁 1 views

## Abstract The inside cover picture shows the human histamine H~2~ receptor and the H~2~ and H~3~/H~4~ receptor‐selective ligands identified. Bioisosteric replacement of the imidazole ring of the __N__^G^‐acyl‐imidazolylpropylguanidine with 2‐aminothiazole yielded potent and selective H~2~ recepto

Discovery of potent and selective histam
✍ H.G.F. Richter; C. Freichel; J. Huwyler; T. Nakagawa; M. Nettekoven; J.-M. Planc 📂 Article 📅 2010 🏛 Elsevier Science 🌐 English ⚖ 453 KB

A novel series of potent histamine H(3) receptor inverse agonists based on the 3,4-dihydro-2H-pyrazino[1,2-a]indol-1-one scaffold has been discovered. Several compounds display high selectivity over other histamine receptor subtypes and have favorable physicochemical properties, low potential for CY