Detection of methadone in human hair by gas chromatography/mass spectrometry
β Scribed by Balabanova, S. ;Arnold, P.J. ;Brunner, H. ;Luckow, V. ;Wolf, H.U.
- Publisher
- Springer-Verlag
- Year
- 1989
- Tongue
- English
- Weight
- 261 KB
- Volume
- 102
- Category
- Article
- ISSN
- 1437-1596
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β¦ Synopsis
Determination of methadone in human hair by gas chromatography/ mass spectrometry was described. Helium as carrier gas, a 30-m bonded phasefused silica DB-1 capillary column and splitless injection at 230Β°C temperature were used. The concentrations of methadone and its metabolites were measured in addition by radioimmunoassay (RIA). Both methods GC/MS and RIA showed the presence of methadone in human hair. Key word: Methadone, in human hair Zusammenfassung. In dieser Arbeit wurde die Bestimmung von Methadon in menschlichen Haaren mittels Gaschromatographie/Massenspektrometrie (GC/MS) beschrieben. Als Tr~igergas wurde Helium benatzt; die S/iule war eine Kapillars/~ule DB-1 un die Injektion eine Splitlos-Injektion, bei einer Verdampfungstemperatur von 230Β°C. Die Methadonkonzentrationen in den Haaren wurden auch mittels Radioimmunoassay (RIA) durchgeftihrt. Beide Methoden GC/MS und RIA zeigen das Vorhandensein des Methadons im menschlichen Haar.
π SIMILAR VOLUMES
A method is described for the determination of the &-agonists clenbuterol and salbutamol in hair. The method involves washing hair in sodium dodecyl hydrogensulphate solution, chemical digestion of the hair matrix in alkaline medium, solid-phase extraction, derivatization with methylboronic acid and