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Detection of iga antibodies against human papillomavirus in cervical secretions from patients with cervical intraepithelial neoplasia

✍ Scribed by Lena Dillner; Zolian Bekassy; Nils Jonsson; Jorge Moreno-Lopez; Jonas Blomberg

Publisher: John Wiley and Sons
Year: 1989
Tongue: French
Weight: 725 KB
Volume: 43
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.2910430109

No coin nor oath required. For personal study only.

✦ Synopsis

Although human papillomavirus (HPV) is involved in the etiology of cervical carcinoma, there are no cervical carcinoma-specific HPV serologic tests available. We investigated the presence of broadly cross-reactive IgA antibodies to papillomavirus (PV) in cervico-vaginal secretions from patients with condylomata and cervical intraepithelial neoplasia (CIN). Purified bovine PV (BPV) virions were used as antigen in an enzyme-linked immunosorbent assay (ELISA). Forty-two women whose ages ranged from 20 to 50 participated in the study. Eight of 9 patients with C I N had IgA antibodies against PV in their cervical secretions. Three of 9 patients with koilocytosis and condylomas but no C I N had IgA antibodies to PV. Six of 24 women with normal Pap-smear and colposcopy also had IgA antibodies against PV in their cervical secretions. The proportion of IgA-positive cervical secretions was significantly higher in the CIN group than in the normal group (p<O.O05).

Our data suggest that IgA antibodies to PV may be a useful marker for CIN.

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