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Detection of hyperdiploid malignant cells in body cavity effusions by fluorescence in Situ hybridization on thinPrep slides

✍ Scribed by Florentine, Barbara D. ;Sanchez, Barry ;Raza, Anwar ;Frankel, Kenneth ;Martin, Sue Ellen ;Kovacs, Bruce ;Felix, Juan C.


Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
258 KB
Volume
81
Category
Article
ISSN
0008-543X

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✦ Synopsis


BACKGROUND.

Benign body cavity effusions sometimes cannot be distinguished from malignant ones by conventional cytology. The authors performed fluores-Barry Sanchez, B


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Interphase cytogenetics by fluorescence in situ hybridization (FISH) can be used to detect malignant cells characterized by chromosomal aneuploidy. However, apparent aneusomy in normal ''control'' tissues has to be considered when using FISH as diagnostic tool. In effusions as model tissue exposed t