## BACKGROUND. Chromosomal abnormalities in some lymphomas are associated with a poor prognosis. Trisomy 12 and deletions of chromosome 13 have been described in small lymphocytic lymphoma (SLL). To determine whether chromosomal aberrations could be detected by fluorescence in situ hybridization (F
โฆ LIBER โฆ
Detection of numerical chromosomal abnormalities by fluorescence in situ hybridization of interphase cell nuclei with chromosome-specific probes on archival cytologic samples
โ Scribed by Ricardo S. Cajulis; Denise Frias-Hidvegi; Gordon H. Yu; Sandra Eggena
- Publisher
- John Wiley and Sons
- Year
- 1996
- Tongue
- English
- Weight
- 373 KB
- Volume
- 14
- Category
- Article
- ISSN
- 8755-1039
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## Background: A fluorescence in situ hybridization (fish) technique using specific dna probes allows for the detection of chromosomal aberrations and gene deletions and gains, even in interphase nuclei in human solid tumors. a high frequency of aberrations of chromosome 17 and mutation of the p53