Seven biopsy specimens from squamous-cell carcinomas of the uterine cervix were examined by RT-PCR for humanpapilloma-virus(HPV)-specific transcripts. With our HPVl8transcription-specific primer pair (5' nts 127-149; 3' nts 587-607), all 7 were shown to contain one strong viral mRNA signal from the
β¦ LIBER β¦
Detection of Human Papillomavirus Type 16 E6/E7 Transcripts in Histologically Cancer-Free Pelvic Lymph Nodes of Patients with Cervical Carcinoma
β Scribed by Barbara R. Rose; Carol H. Thompson; Xing-Mai Jiang; Martin H.N. Tattersall; Peter M. Elliott; Christopher Dalrymple; Yvonne E. Cossart
- Book ID
- 115616066
- Publisher
- Elsevier Science
- Year
- 1994
- Tongue
- English
- Weight
- 379 KB
- Volume
- 52
- Category
- Article
- ISSN
- 0090-8258
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Certain human papillomaviruses (HPV), mainly types 16 and 18, have been widely recognized as an essential etiologic factor for the development of carcinoma of the uterine cervix. The early HPV proteins E6 and E7 are consistently expressed in the tumor cells, and cervical-carcinoma patients can devel