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Detection of hepatitis C virus with RNA polymerase chain reaction in fulminant hepatic failure

✍ Scribed by Federico G. Villamil; Ke-Qin Hu; Chang-Hong Yu; Chao-Hung Lee; Sergio E. Rojter; Luis G. Podesta; Leonard Makowka; Stephen A. Geller; John M. Vierling

Book ID
119155929
Publisher
John Wiley and Sons
Year
1995
Tongue
English
Weight
864 KB
Volume
22
Category
Article
ISSN
0270-9139

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Detection of hepatitis C virus with RNA
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The role of hepatitis C virus (HCV) infection in fulminant hepatic failure is controversial. The frequency of serum HCV RNA positivity in previously reported patients with fulminant hepatic failure (FHF) of indeterminate cause ranged from 0 to 12% in the United States and Europe and from 43% to 59%

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Although detection of hepatitis C virus RNA with polymerase chain reaction has become the standard for diagnosis, extensive application has been thwarted by polymerase chain reaction's labor intensiveness, risk of false-positive results through contamination and time required for individual assays.

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## Abstract The mean prevalence of anti‐hepatitis C virus (HCV) in Italy is 0.87%. It reaches 2% in Campania, Southern Italy. Approximately 50% of community acquired non‐A, non‐B (NANB) hepatitis cannot be associated with known parenteral exposure. A recent Italian study has shown that the only dem