## Abstract The ordered subset analysis (OSA) method allows for the incorporation of covariates into the linkage analysis of a dichotomous disease phenotype in order to reduce genetic heterogeneity. Complex human diseases may involve geneβenvironment (G Γ E) interactions, which represent a special
Detection of Gene-Environment Interactions in Joint Segregation and Linkage Analysis
β Scribed by W. James Gauderman; Cheryl L. Faucett
- Book ID
- 117852202
- Publisher
- American Society of Human Genetics
- Year
- 1997
- Tongue
- English
- Weight
- 185 KB
- Volume
- 61
- Category
- Article
- ISSN
- 0002-9297
- DOI
- 10.1086/301597
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Our goal was to determine the degree to which joint segregation and linkage analysis leads to increased efficiency for estimating the recombination fraction and to greater power for detecting linkage, compared to separate analyses. We concentrated on the quantitative phenotype Q2 and analyzed linkag
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