Detection of familial adenomatous polyposis with orthogonal polarized spectroscopy of the oral mucosa vasculature

✍ Scribed by Ali Basiri; Daniel L. Edelstein; Jenna Graham; Afshin Nabili; Francis M. Giardiello; Jessica C. Ramella-Roman

• Book ID: 102291588
• Publisher: John Wiley and Sons
• Year: 2011
• Tongue: English
• Weight: 415 KB
• Volume: 4
• Category: Article
• ISSN: 1864-063X
• DOI: 10.1002/jbio.201100057

✦ Synopsis

Abstract

Familial Adenomatous Polyposis (FAP) is an autosomal dominant disease characterized by the development of multiple colonic polyps at younger age with a near 100% lifetime risk of colorectal cancer. The determination of FAP is made after extensive clinical evaluation and genetic testing of at risk individuals. We investigated a novel spectro‐polarimetric imaging system capable of capturing high‐resolution images of the oral mucosa at different wavelengths in an attempt to distinguish patients with FAP from controls. Results of a clinical trial show that the system is capable of separating FAP positive individuals from controls by measuring the individuals' oral vascular density and complexity. (© 2011 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)