Germline mutations in the tumor-suppresor APC gene are associated with hereditary familial adenomatous polyposis (FAP) and somatic mutations are common in sporadic colorectal cancer. In this study, we report the identification of three novel germline mutations: 1682-1683insA, 3252-3253insAT, 3544A>T
β¦ LIBER β¦
Early detection of nonpolypoid cancers in the rectal remnant in patients with familial adenomatous polyposis/gardner's syndrome
β Scribed by Takayuki Matsumoto; Mitsuo Iida; Shuji Tada; Ryuuichi Mibu; Takashi Yao; Masatoshi Fujishima
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 918 KB
- Volume
- 74
- Category
- Article
- ISSN
- 0008-543X
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## Abstract In an investigation devoted to the search for plasma markers for colorectal cancer (CRC), carried out by matrixβassisted laser desorption/ionization (MALDI) mass spectrometry, a series of overexpressed peptides were identified in the plasma of patients. Among them the peptide with molec