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Detection of COL1A1-PDGFB fusion transcripts and PDGFB/PDGFRB mRNA expression in dermatofibrosarcoma protuberans

✍ Scribed by Takahira, Tomonari; Oda, Yoshinao; Tamiya, Sadafumi; Higaki, Koichi; Yamamoto, Hidetaka; Kobayashi, Chikashi; Izumi, Teiyu; Tateishi, Naomi; Iwamoto, Yukihide; Tsuneyoshi, Masazumi


Book ID
109889577
Publisher
Nature Publishing Group
Year
2007
Tongue
English
Weight
355 KB
Volume
20
Category
Article
ISSN
0893-3952

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Dermatofibrosarcoma protuberans (DP), an infiltrative skin tumor of intermediate malignancy, presents specific cytogenetic features such as reciprocal translocations t(17;22)(q22;q13.1) or, more often, supernumerary ring chromosomes derived from t(17;22). Different translocations, including t(2;17)

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Dermatofibrosarcoma protuberans (DFSP) and its juvenile form, giant-cell fibroblastoma (GCF), are uncommon infiltrative tumors of the dermis, which present unique cytogenetic features, such as the reciprocal translocation t(17;22) or, more commonly, supernumerary ring chromosomes containing sequence