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Detection of COL1A1–PDGFB fusion transcripts and platelet-derived growth factor α and β receptors in giant cell fibroblastoma of the postsacrococcygeal region

✍ Scribed by A. Kashima; A. Yamashita; S. Moriguchi; K. Marutsuka; S. Tsumori; K. Yoshizato; A. Ishihara; M. Setoyama; Y. Asada

Book ID
108668704
Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
573 KB
Volume
154
Category
Article
ISSN
0007-0963

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Various regions within the alpha-helical
Various regions within the alpha-helical domain of the COL1A1 gene are fused to the second exon of the PDGFB gene in dermatofibrosarcomas and giant-cell fibroblastomas
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Dermatofibrosarcoma protuberans (DFSP) and its juvenile form, giant-cell fibroblastoma (GCF), are uncommon infiltrative tumors of the dermis, which present unique cytogenetic features, such as the reciprocal translocation t(17;22) or, more commonly, supernumerary ring chromosomes containing sequence