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Detection of choline-acetyltransferase activity in lymphocytes

✍ Scribed by I. Rinner; K. Schauenstein

Publisher
John Wiley and Sons
Year
1993
Tongue
English
Weight
371 KB
Volume
35
Category
Article
ISSN
0360-4012

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✦ Synopsis

Abstract

The cholinergic system takes part in the immune‐neuroendocrine interation. Lymphocytes have been found to express muscarinic and nicotinic cholinergic receptors, as well as acetylcholine‐esterase on their surface, and cholinergic agents modulate immune functions in vitro and in vivo. In the present study we provide evidence that purified organ resident and circulating lymphocytes, as well as various lymphoid cell lines derived from different species, exhibit choline‐acetyltransferase activity and, therefore, have the potential to produce the neurotransmitter acetylcholine. © 1993 Wiley‐Liss, Inc.

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