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Choline acetyltransferase activity in murine thymus

โœ Scribed by Dr. M. A. Tria; G. Vantini; M. G. Fiori; A. Rossi

Publisher
John Wiley and Sons
Year
1992
Tongue
English
Weight
573 KB
Volume
31
Category
Article
ISSN
0360-4012

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โœฆ Synopsis

Murine thymus has been demonstrated to contain both cholinergic receptors and acetylcholinesterase activity. In the present study we have investigated the presence of the enzyme choline acetyltransferase in this organ, which is responsible for the synthesis of acetylcholine. Results reported here demonstrate that (1) an appreciable amount of the enzyme is already present in the thymus on the day of birth; (2) its expression is developmentally regulated; and (3) thymic atrophy, induced in young (2-week-old) and adult (6-week-old) mice by i.p. injection of hydrocortisone for 2 days, is accompanied by significant reduction of choline acetyltransferase activity only in young mice.

Altogether these results demonstrate the presence in the murine thymus of functionally relevant markers of the cholinergic system that might interface the interactions between the nervous and immune systems.

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