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Detection of c-erbB-2 protein and mRNA overexpression by immunohistochemistry and in situ hybridization in human breast carcinoma


Book ID
116104881
Publisher
Elsevier Science
Year
1996
Tongue
English
Weight
70 KB
Volume
64
Category
Article
ISSN
0167-0115

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The c-erbB-2 proto-oncogene is amplified in a high percentage of primary human breast tumors, suggesting that the overexpression of this gene may be involved in the development of human breast cancer. We have investigated five human breast tumor cell lines and have detected amplified c-erbB-2 gene c