Interphase FISH detection of BCL2 rearra
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Jan-Willem Vaandrager; Ed Schuuring; Ton Raap; Katja Philippo; Karin Kleiverda;
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Article
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2000
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John Wiley and Sons
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English
β 188 KB
Rearrangement of the BCL2 gene is an important parameter for the differential diagnosis of non-Hodgkin lymphomas. Although a relatively large proportion of breakpoints is clustered, many are missed by standard PCR. A FISH assay is therefore desired. Up to now, a lack of probes flanking the BCL2 gene