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Characterisation of BCL2-JH rearrangements in follicular lymphoma: PCR detection of 3′ BCL2 breakpoints and evidence of a new cluster

✍ Scribed by Buchonnet, G; Lenain, P; Ruminy, P; Lepretre, S; Stamatoullas, A; Parmentier, F; Jardin, F; Duval, C; Tilly, H; Bastard, C

Book ID
110054663
Publisher
Nature Publishing Group
Year
2000
Tongue
English
Weight
693 KB
Volume
14
Category
Article
ISSN
0887-6924

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Interphase FISH detection of BCL2 rearra
Interphase FISH detection of BCL2 rearrangement in follicular lymphoma using breakpoint-flanking probes
✍ Jan-Willem Vaandrager; Ed Schuuring; Ton Raap; Katja Philippo; Karin Kleiverda; 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 188 KB

Rearrangement of the BCL2 gene is an important parameter for the differential diagnosis of non-Hodgkin lymphomas. Although a relatively large proportion of breakpoints is clustered, many are missed by standard PCR. A FISH assay is therefore desired. Up to now, a lack of probes flanking the BCL2 gene