Detection of a Novel Variant Human Hemoglobin by Electrospray Ionization Mass Spectrometry
β Scribed by Heinz Troxler; Frank Neuheiser; Peter Kleinert; Thomas Kuster; Claus W. Heizmann; Ragna Sack; Peter Hunziker; Thomas J. Neuhaus; Marlis Schmid; Hannes Frischknecht
- Book ID
- 115589798
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 54 KB
- Volume
- 292
- Category
- Article
- ISSN
- 0006-291X
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Glycated hemoglobin, considered to be the best index for the treatment of diabetes mellitus, was measured by electrospray ionization mass spectrometry (ESI/MS) according to the method proposed by Morris et al. at the 44th ASMS Conference on Mass Spectrometry and Allied Topics, 1996. They compared th
## Abstract Electrospray ionization mass spectrometry (ESIβMS) has been used to characterize the denaturation of porcine hemoglobin (Hb) induced by solvent changes. This work provides evidence for the symmetric nature of Hb denaturation and demonstrates that heme losses from Ξ±β and Ξ²βmonomers occur