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Detection and reduction of microaggregates in insulin preparations

✍ Scribed by Caryn L. Heldt; Mirco Sorci; David Posada; Amir Hirsa; Georges Belfort

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
794 KB
Volume
108
Category
Article
ISSN
0006-3592

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## Abstract During in vitro incubation in the absence or presence of insulin, glycogen depletion occurs in the inner core of the muscle specimen, concomitant with increased staining of hypoxia‐induced‐factor‐1‐alpha and caspase‐3, markers of hypoxia and apoptosis, respectively. The aim of this stud