Detection and cytotoxicity of cisplatin-induced superoxide anion in monolayer cultures of a human ovarian cancer cell line
✍ Scribed by Hidetaka Masuda; Toshiko Tanaka; Masahiro Tateishi; Mariko Naito; Hisamitsu Tamai
- Publisher
- Springer
- Year
- 2001
- Tongue
- English
- Weight
- 119 KB
- Volume
- 47
- Category
- Article
- ISSN
- 0344-5704
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## Abstract The clinical efficacy of cisplatin‐based chemotherapy for ovarian cancer is frequently compromised by drug resistance or dose‐limiting renal and neurologic toxicities. CI‐973 (NK‐121), a 2‐methyl‐1, 4‐butanediamine analogue of carboplatin, has shown little nephro‐and neuro‐toxicity in p
## Abstract Human ovarian carcinoma cells (2008 and its cisplatin‐resistant sub‐line 2008/C13\*) were sensitized to cisplatin by treatment with human recombinant gamma interferon (IFNγ). IFNγ produced no significant change in the uptake of CDDP. Exposure of 2008 and 2008/C13\* cells to IFNγ resulte