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Detection and characterisation of human astroviruses in children with acute gastroenteritis in Blantyre, Malawi

✍ Scribed by Nigel A. Cunliffe; Winifred Dove; Jailosi S. Gondwe; Benson D.M. Thindwa; Julie Greensill; Jennifer L. Holmes; Joseph S. Bresee; Stephan S. Monroe; Roger I. Glass; Robin L. Broadhead; Malcolm E. Molyneux; C. Anthony Hart

Publisher
John Wiley and Sons
Year
2002
Tongue
English
Weight
61 KB
Volume
67
Category
Article
ISSN
0146-6615

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✦ Synopsis

Abstract

In a 2‐year hospital‐based study of paediatric gastroenteritis in Blantyre, Malawi, astroviruses were detected by enzyme immunoassay in 15 (1.9%) of 786 inpatients and in 9 (2.3%) of 400 outpatients. Greater disease severity was noted in children coinfected with human immunodeficiency virus (HIV). Six human astrovirus (HAstV) genotypes were identified, including HAstV‐1 (25%), HAstV‐2 (21%), HAstV‐3 (25%), HAstV‐4 (13%), HAstV‐5 (4%), and HAstV‐8 (13%). Although astroviruses are not major causes of gastroenteritis among children admitted to hospital in Blantyre, concomitant HIV infection appears to be a risk factor for increased severity of disease. J. Med. Virol. 67:563–566, 2002. © 2002 Wiley‐Liss, Inc.

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